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Casanova, Emilio

Research Topics

  • Lung Cancer
  • Inflammation
  • Targeted therapy
  • Immunotherapy

Aktuelle Forschungsprojekte

Lung cancer is the most frequent cancer with an aggressive clinical course and high mortality rates. Most cases are diagnosed at advanced stages when treatment options are limited and the efficacy of chemotherapy is poor. The disease has a complex and heterogeneous background with non-small-cell lung cancer (NSCLC) accounting for 85% of patients and lung adenocarcinoma being the most common histological subtype. Almost 30% of lung adenocarcinomas are driven by an activating Kirsten rat sarcoma viral oncogene homolog (KRAS) mutation. We are interested in developing therapeutic strategies tailored for KRAS driven NSCLC relying on the blockage of KRAS functional output, cellular dependencies, metabolic features and immunotherapy.

 

Selected Publications