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Gruber, Christian

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Gemeinsame Einrichtung für Massenspektrometrie

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  • Dr. Roland Hellinger
  • PhD Students
  • Diploma and Master Students
  • International Exchange Students

Research Interests

  1. Physiology and Pharmacology of Neuropeptides and their Receptors
  2. Molecular Pharmacology of G Protein-Coupled Receptors
  3. Drug Discovery of Peptide Therapeutics
  4. Peptidomics of Nature-Derived Peptides from Plants and Invertebrates

Selected publications

  • Koehbach J, O’Brien M, Muttenthaler M, Miazzo M, Akcan M, Elliott AG, Daly NL, Harvey PJ, Arrowsmith S, Gunasekera S, Smith TJ, Wray S, Göransson U, Dawson PE, Craik DJ, Freissmuth M, Gruber CW. Oxytocic plant cyclotides as templates for peptide G protein-coupled receptor ligand design. Proceedings of the National Academy of Sciences of the United States of America 110: 21183-88, 2013.
  • Thell K, Hellinger R, Sahin E, Michenthaler P, Gold-Binder M, Haider T, Kuttke M, Liutkeviciute Z, Göransson U, Gründemann C, Schabbauer G, Gruber CW. Oral activity of a nature-derived cyclic peptide for the treatment of multiple sclerosis. Proceedings of the National Academy of Sciences of the United States of America 113: 3960–65, 2016.
  • Muratspahić E, Tomašević N, Koehbach J, Duerrauer L, Hadžić S, Castro J, Schober G, Sideromenos S, Clark RJ, Brierley SM, Craik DJ, Gruber CW. Design of a stable cyclic peptide analgesic derived from sunflower seeds that targets the κ-opioid receptor for the treatment of chronic abdominal pain. Journal of Medicinal Chemistry 64: 9042-9055, 2021.
  • Atanasov AG, …, Gruber CW, et al. Natural products in drug discovery: advances and opportunities. Nature Reviews in Drug Discovery 20: 200-216, 2021.
  • Muratspahic E, Freissmuth M, Gruber CW. Nature-derived peptides – a growing niche for GPCR ligand discovery. Trends in Pharmacological Sciences 40: 309-326, 2019.