Assoc.Prof. Steffen Sinning
Aarhus University, Denmark
Department of Forensic Medicine
Programm
“Development of fluorescent biosensors for serotonin: Applications in neuroscience and molecular pharmacology”
Serotonin is a neurotransmitter that plays a central role in regulating mood and various behaviors. The serotonergic system is linked to depression and is a key target of antidepressants, amphetamine‑like compounds, and psychedelic drugs. Monitoring serotonin dynamics both in vitro and in vivo is essential for understanding psychiatric disorders and the mechanisms of drug action.
Genetically encoded fluorescent biosensors are engineered proteins that detect specific molecules, such as serotonin, and convert this detection into a fluorescent signal. A major advantage of these sensors is their ability to track serotonin fluctuations in real time with high spatial and temporal resolution.
In this presentation, the development process of our fluorescent biosensors is described and their application across a range of in vitro and in vivo systems is shown to illustrate how they can be used to investigate brain function and drug effects.
Host: Walter Sandtner
Contact for questions: Helmut KUBISTA