Dr. Claudia Stäubert
Rudolf-Schönheimer-Institut für Biochemie
Universität Leipzig
Medizinische Fakultät
Program
"Succinate receptor 1 signaling mutually depends on subcellular localization and cellular metabolism"
Succinate is a key metabolite of the tricarboxylic acid cycle that specifically activates the Gi- and Gq-coupled succinate receptor 1 (SUCNR1). Succinate and SUCNR1 signaling have been reported to exhibit both pro- and anti-inflammatory effects. We investigated the link between metabolism, SUCNR1 signaling, and its subcellular localization, which revealed that the modulation of the available energy substrates (glucose versus glutamine) results in changes in SUCNR1 signaling and localization. In M2-like macrophages, endogenous SUCNR1-mediated Gi signaling enhances glycolysis, while Gq signaling suppresses it. Our findings indicate that metabolic context shapes spatially dependent SUCNR1 signaling, regulating cellular energy balance and adapting to fluctuations in succinate levels.
Host: Marian SLAK-RUPNIK
Contact for questions: Helmut KUBISTA