Institute of Biological Information Processing
Molecular and Cellular Physiology (IBI-1)
Forschungszentrum Jülich GmbH
Website Christoph Fahlke
”Regulation of intracellular chloride concentrations”
Chloride is the main physiological anion. There are various secondary-active Cl- transporters that generate gradients across surface membranes and the membranes of intracellular compartments, which are utilized in multiple cellular processes. In the central nervous system, inhibitory synaptic transmission requires low [Cl-]int in postsynaptic neurons. At excitatory synapses, changes in [Cl-]int may alter glutamate loading of synaptic vesicles and affect its release. In neurons and glial cells, GABA uptake is stoichiometrically coupled to Cl- transport. In all cells, Cl- fluxes through channels or transporters are necessary for volume regulatory processes, and high lysosomal [Cl-] appears to support membrane integrity. The talk will summarize report recent work of my laboratory on mechanisms that regulate cytoplasmic and organelle [Cl-] in glial cells, in synaptic vesicles and in lysosome. Special emphasis will be on the role of neurotransmitter transporters and on alterations of [Cl-] in human diseases.
Host: Harald SITTE
Contact for questions: Helmut KUBISTA